Philipp E. Schilling

Philipp E. Schilling

Postdoctoral Researcher · Stanford University

Amide-forming KAT ligation and organoboron protecting groups that make chemical protein synthesis possible at micromolar concentrations.

Research areas

Research areas: Chemical protein synthesis, KAT ligation (potassium acyltrifluoroborate ligation), Organoboron chemistry, Protecting groups for solid-phase peptide synthesis, Chemoselective amide-forming ligation, Peptide and protein chemistry, Bioconjugation.

Selected publications

  1. Zwitterionic organoboron complexes for overcoming the concentration barrier in chemical protein synthesis
    Philipp E. Schilling, Samuel Steiner, Jeffrey W. Bode
    Science 2026, 391 · doi:10.1126/science.aea7511
  2. Preparation of Potassium Acyltrifluoroborates (KATs) from Carboxylic Acids by Copper-Catalyzed Borylation of Mixed Anhydrides
    Pinku Tung, Anne Schuhmacher, Philipp E. Schilling, Jeffrey W. Bode, Neal P. Mankad
    Angew. Chem. Int. Ed. 2021, 61 · doi:10.1002/anie.202114513

All publications →

Research topic

KAT ligation: an overview of potassium acyltrifluoroborate amide-forming ligation and its use in chemical protein synthesis.

Tools

Ligation site finder: paste a protein sequence to find NCL, STL, KAHA and KAT ligation sites, in your browser.

Profiles